Effect of Zero-time Exercise Intervention on Cancer-related Fatigue and Immunonutritional Status in Patients with Liver Cancer Undergoing Interventional Therapy: a Randomized Controlled Trial

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Experimental Group:On the basis of routine care, a fragmented micro‐exercise management based on the "Exercise Snacks" concept is implemented for 12 weeks: Exercise Library: 1. Lying/Sitting position (for postoperative immobilization or weakness): Ankle pump exercises, upper limb gripping (with a grip ball), and abdominal breathing ; 2. Standing position (for waiting or infusion intervals): Heel raises (holding a chair back) and wall squats (half squats) ; 3. Walking position (for ward corridors or home): Arm‐swinging brisk walking. ;Control Group:Patients receive standard perioperative care for TACE/HAIC, including complication observation, routine discharge guidance, and general dietary reminders. Activity guidance follows the conventional advice of "rest properly and take appropriate activities" without any specific exercise prescriptions.; CONDITION: Liver Cancer PRIMARY OUTCOME: Cancer‐related Fatigue (CRF); SECONDARY OUTCOME: Prognostic Nutritional Inde X(PNI);Neutrophil‐to‐Lymphocyte Ratio (NLR);Albumin‐Bilirubin (ALBI) score;Treatment Adherence;Quality of Life; INCLUSION CRITERIA: 1.Aged 18‐75 years, regardless of gender. 2.Diagnosed with primary hepatocellular carcinoma (HCC) by pathology or imaging. 3.Planned to undergo TACE or HAIC treatment, and evaluated by the attending physician as requiring multiple subsequent treatments. 4.Baseline liver function Child‐Pugh class A or B; ECOG performance status score 0‐1. 5.Clear consciousness, capable of verbal communication, and able to cooperate in using smartphones or logs to record exercise status. 6.Fully understand the content of this study, voluntarily participate, and sign the informed consent form.
Epistemonikos ID: 79f987083970a0a9680828a4f8fba6985b713cdd
First added on: Oct 08, 2026