Training to Enhance Cognition in Older Adults

This is a planning trial to optimize procedures for a larger clinical trial. Participants will be randomized into one of two groups‐‐an active group that has intervention training after initial visit and a wait control group that begins intervention after 12 weeks. All participants will receive in‐lab baseline testing including IQ (WASI‐II), a medical/psychiatric history questionnaire, a depression screen (Geriatric Depression Scale Short Form) and a pre‐training battery that includes selected tests from the NIH toolbox, the Repeatable Battery for Neuropsychological Status (RBANS), a Useful Field of View task (UFOV), a driving simulator task, a dual (motor‐cognitive) task, an n‐back task with and without distractors(with EEG) and 6 minutes of resting state EEG. Participants will be trained to use the game system and play the game at the pre‐training in‐lab visit. Participants will be provided with a PC with eye‐tracker that has training game software installed. Participants will play intervention training games at home for 8‐12 weeks with in‐lab assessments (the pre‐training battery described above). Participants will be asked to play the training games a minimum of 5 times per week for 30 minutes at a time. Compliance will be monitored daily over a secure internet connection. If a participant has played less than the required time in a given week, a research associate will contact the participant to inquire about potential problems and to encourage the participant to resume or increase training time. The first group of 36 participants will receive post‐training assessments at 8 weeks, 12 weeks and 6 months. The second group of 36 participants will have an additional pre‐training session with structural and functional imaging and will receive only pre‐ and post‐training assessment.