Efficacy of oranexidine gluconate in the prevention of catheter-related bloodstream infections

INTERVENTION: Intervention: 1.5% Oranexidine gluconate solution (Otsuka Pharmaceutical Factory, Inc.) Control: 1% chlorhexidine alcohol (Toho Yakuhin Co.,Ltd) CONDITION: Patients 18 years of age or older admitted to the ICU or HCU with a newly inserted central venous catheter, dialysis catheter and arterial catheter PRIMARY OUTCOME: Incidence of catheter‐related infections SECONDARY OUTCOME: 1) Incidence of catheter‐related infections (per 1000 catheters/day); 2) In‐hospital mortality rate; 3) ICU mortality rate; 4) Incidence of resistant bacteria (MRSA, Pseudomonas aeruginosa, VRE); 5) Adverse events (redness, urticaria, anaphylaxis, etc.) INCLUSION CRITERIA: