High willingness to receive a vaccine for gonorrhoea prevention among gay, bisexual, queer, and other sexuality diverse men, and non-binary people in Australia

Gonorrhoea incidence and antimicrobial resistance are increasing among gay, bisexual, queer, and other sexuality diverse men, and non-binary (GBQ+) people. Observational studies suggested that 4CMenB vaccine (Bexsero®) may provide partial protection against gonorrhoea, but recent randomised trials found no clear evidence of protection. We analysed willingness to receive 4CMenB for gonorrhoea prevention in a 2025 Australian cross-sectional survey of GBQ+ individuals aged ≥16years. Multivariable logistic regression examined associated factors. Among 2138 participants (median age 39years), 89.2% were willing to be vaccinated. Willingness was lower among participants aged ≥30 (aOR=0.46;95%CI=0.29–0.74), born outside Australia (aOR=0.71;95%CI=0.51–0.99), higher among those reporting recent HIV PrEP use (aOR=2.80;95%CI=1.30–5.99), familiarity with antimicrobial resistance (aOR=2.26;95%CI=1.61–3.18), and willingness to take an antibiotic pill after sex to prevent STIs (aOR=5.42;95%CI=3.85–7.61). Willingness was high and aligned more with prevention engagement and biomedical prevention attitudes than with sexual risk behaviours, suggesting future gonorrhoea vaccines may be acceptable in this population.