Clinical study on neuroimaging features and rehabilitation strategies of post-stroke frontal lobe alien hand syndrome

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Intervention group(Research Topic 1):The transcranial time‐interferometric electrical stimulation regulation system (model NeuroStim non‐invasive deep brain regulation system, Anhui Fuqing) will generate dual‐frequency current to selectively regulate the motor auxiliary area, anterior cingulate gyrus and medial prefrontal lobe on the affected side.;Control group(Research Topic 1):Conventional drug treatment and rehabilitation therapy are provided. Symptomatic drug treatments such as anti‐platelet aggregation, plaque stabilization, nerve nutrition, and microcirculation improvement are given based on the condition, as well as secondary prevention of stroke.;Frontal lobe AHS patient group (Research Topic 2):None;Healthy control group (Research Topic 2):None;Genu Infarction Group (Group G) (Research Topic 3):None;Body Infarction Group (Group B) (Research Topic 3):None;splenium Infarction Group (Group S) (Research Topic 3):None;Control group of non‐corpus callosum infarction (Research Topic 3):None;Healthy control group (Research Topic 3):None; CONDITION: Cerebral infarction in the ACA blood supply area PRIMARY OUTCOME: The upper extremities motor function test of Fugl‐ Meyer movement assessment;Frontal assessment battery;The Frontal Lobe Alien Hand Syndrome Core Symptom Assessment Scale; SECONDARY OUTCOME: Wolf hand motor function assessment;Monspaneal cognitive assessment;Safety Indicators:;Motor evoked potentials; INCLUSION CRITERIA: Research Topic 1: 1.Cerebral infarction in the ACA blood supply area confirmed by cranial MRI; 2.Clinical manifestations meet the diagnostic criteria for frontal lobe AHS, namely, the presence of involuntary compulsive grasping, motor resistance or contralateral hand interference in the affected upper limb, and the patient subjectively denies that the movement is of their own volition; 3.Age 18‐85; 4.All cases were verified by the rubber hand illusion test. Research Topic 2: Patient group: 1.Cerebral infarction in the ACA blood supply area confirmed by cranial MRI; 2.Clinical manifestations meet the diagnostic criteria for frontal lobe AHS, namely, the presence of involuntary compulsive grasping, motor resistance or contralateral hand interference in the affected upper limb, and the patient subjectively denies that the movement is of their own volition; 3.Age 18‐85; 4.All cases were verified by the rubber hand illusion test. Cont
Epistemonikos ID: 77b51b4d4998f17107ba9828671fa36d56ae1f52
First added on: Oct 08, 2026