Randomized controlled trial of esophagectomy versus chemoradiotherapy in patients with clinical stage I esophageal carcinoma JCOG0502

INTERVENTION: A:Esophagectomy with D2 (or more) lymph node desection B:Chemoradiation 5FU 700mg/m2/day civ Day1‐4, 29‐32 CDDP 70mg/m2/day div Day1, 29 radiation 60Gy/30fr/6w CONDITION: Esophageal Carcinoma PRIMARY OUTCOME: Overall Survival SECONDARY OUTCOME: Complete Response Rate, Adverse Events INCLUSION CRITERIA: (1)Histologically proven esophageal cancer (squamous cell carcinoma, adenosquamous cell carcinoma, besaloid carcinoma) (2)all lesions are localized in thoracic esophagus. (3)The depth of main lesion is endoscopically diagnosed submucosa. (4)No lymphnode metastasis and no distant metastasis. (5)No prior chemotherapy and/or radiotherapy. Only curative endoscopic mucosal resection is allowed. (6)ages 20 years‐75years (7)PS(ECOG) 0‐1 (8)Normal organic function. (9)oral or written informed consent obtained before randomization