Efficacy of Cilostazol in Prevention of Peripheral Neuropathy

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2022
There are several mechanisms concerning pathophysiology of paclitaxel induced peripheral neuropathy. One of the main mechanisms is induction of Schwann cell dedifferentiation by paclitaxel. At the preclinical level, cilostazol potently inhibited paclitaxel-induced dedifferentiation of cultured Schwann cells, yet this positive effect have not been clinically investigated.
Epistemonikos ID: 76e0b71a0cc165abb4383229af03ce65d7645689
First added on: May 10, 2024