Effect of garlic on typhoid fever

Authors
Category Primary study
Registry of TrialsClinical Trials Registry - India
Year 2011
INTERVENTION: Intervention1: Allium sativum (garlic) : Above treatment + Allium sativum (garlic) 1 gram Q6H Control Intervention1: Allium sativum (garlic) : Allium sativum (garlic) 1 gram Q6H Control Intervention2: Drugs according to IAP protocole: treatment as per current unit policy for treatment of enteric fever. The standardized unit policy for children admitted with enteric is to use intravenous (IV) Ceftriaxone at a dose of 100 mg/kg/day. If fever is unresponsive, oral Azithromycin (20 mg/kg/day) is added on 4th day. Antibiotics may be changed in culture positive cases according to sensitivity pattern. Complicated cases may be admitted into the PICU and if made nil per oral they will move out of the trial but be included in the analysis according to intention to treat. If culture is not positive and fever is unresponsive for 8 days then IV Levofloxacin (10 mg/ kg/ day) is added as third line antibiotic. IV Aztreonam is used as fourth line antibiotic (50‐100mg/kg/day) if fever is unresponsive to above treatment. CONDITION: enteric fever PRIMARY OUTCOME: To examine if adding allium sativum as food supplement to the standard antibiotic regime of children admitted to the hospital with a diagnosis of enteric fever on can be beneficial to reduce the duration of illness. ; Primary outcome measure: ; ‐Duration of febrile period. ; ‐‐‐‐‐‐Timepoint: 1 yr SECONDARY OUTCOME: 1. Duration of hospital stay.‐‐‐‐‐‐Timepoint: 1 year INCLUSION CRITERIA: All the children aged 5 years to 12 years, admitted in children ward with confirmed diagnosis of enteric fever
Epistemonikos ID: 75e07b8ef1ae112bc4317f787f8165732572f7db
First added on: Aug 22, 2024