Multi-institute randomized study of natural type interferon alpha for patients with renal cell carcinoma after radical nephrectomy

INTERVENTION: Administration of natural type interferon alpha for at least one year Observation CONDITION: Renal cell carcinoma PRIMARY OUTCOME: Local recurrence and distant metastasis INCLUSION CRITERIA: Pathologically confirmed RCC After radical nephrectomy Stage II or III Performance Status 0 to 2 WBC count 3500 or over PLT count 100000 or over AST, ALT within 2.5 times of institute reference level Creatinine 2.0mg/dl or less Total bilirubin within 1.5 times of institute reference level Written informed consented No prior chemotherapy nor immuno‐ therapy