Impact of Curcumin Application on Lichen Planus Oral lesions

INTERVENTION: Clinical Trial Curcumin Drug Experimental group: 7 patients with oral lichen planus lesions diagnosed clinically and histopathologically applied topically 3x / day nanoparticulate curcumin over the lesions for a period of 30 days. Control group: 8 patients with oral lichen planus lesions clinically‐histopathologically applied topically 3x / day of empty nanoparticle on the lesions also for a period of 30 days. The patients were divided between the 2 groups through a simple randomization generated by an online program. Nanoparticles CONDITION: Lichen planus Lichen planus ; Lichen planus PRIMARY OUTCOME: Reduction of symptoms and signs of oral lichen planus using the Visual Analogue Scale and Thongprasom Classification, respectively, assessed weekly during active treatment (30 days) and 30, 60 and 90 days after the end of treatment. SECONDARY OUTCOME: Modulation of the expression of the transcription factor NF‐B and the amount of T cells present by immunohistochemical analysis comparing the biopsy performed at the end of treatment with the initial biopsy. INCLUSION CRITERIA: Clinical and histopathological diagnosis of OLP, based on World Health Organization criteria modified by van Der Meij et al.. These criteria take into account the association between clinical criteria (presence of bilateral lesions, more or less symmetrical; appearance of grayish and white line‐shaped plaques with reticular characteristic; erosive, atrophic, bullous and plaque lesions associated with reticular lesions in any location of the oral mucosa); and histopathological criteria (presence of a well‐defined zone of cellular infiltrate in the form of a band, with increased number of intra‐epithelial lymphocytes as well as signs of degeneration in the basal cell layer and absence of epithelial dysplasia; keratinocyte apoptosis in the intra‐epithelial region. Associated with the clinical‐histopathological diagnosis of OLP, patients should be over 18 years old and have painful symptoms.