Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2).

In a previous study the efficacy of Lb CD2 on interim covariates related to caries development was tested. So, it was decided to plan a new study on schoolchildren from the same area. The aim of the present research protocol was to evaluate the anticariogenic effect of probiotics daily used, on the caries development in children. The null hypothesis was that the probiotic Lb CD2 would not modify the caries risk of the children. Moreover, the study will be carried out to investigate the plaque acidogenicity in situ following the regular consumption of a probiotic product compared to a control group. Objective: To determine the effect of a regularly consumed probiotic on the development of new caries lesions. Study design: Double blind, placebo-controlled, longitudinal study, monocentric, national, in situ