Dextran 40 Plus Ringer's Lactate Vs. Ringer's Lactate Alone for Fluid Resuscitation in Acute Pancreatitis

Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2025
This clinical trial aims to learn if a combination of Dextran 40 and Ringer\'s lactate solution can improve fluid resuscitation in mild and moderate acute pancreatitis (AP) and prevent complications. The main questions it aims to answer are: Does early fluid resuscitation with Dextran 40 plus Ringer\'s lactate improve patient outcomes compared to Ringer\'s alone? Does this treatment reduce inflammation, organ failure, and the need for intensive care unit (ICU) admission? Researchers will compare Dextran 40 plus Ringer\'s lactate to Ringer\'s alone to see if the combination therapy is more effective in reducing disease severity and complications. Participants will: Receive either Dextran 40 plus Ringer\'s lactate (1:3 ratio) or Ringer\'s lactate alone. Have blood tests every 24 hours to measure inflammation and organ function. Be monitored for changes in disease severity, need for ICU admission, and hospitalization duration. This study will help determine the best fluid resuscitation strategy for treating mild and moderate acute pancreatitis.
Epistemonikos ID: 74259c3d9ad50ed87282b416e042b9c87a2c872c
First added on: Mar 01, 2025