Investigating whether different doses of Fruitflow have equal impact on blood platelets in different healthy subjects

INTERVENTION: The study sets out to examine whether 5 different doses of Fruitflow (0, 30, 75, and 300 mg) are equivalent to the standard daily dose of 150mg. The study will follow a double‐blind randomised crossover design, in which five masked interventions will be administered to each subject, with interventions separated by a minimum of 10 days. CONDITION: Reduction of platelet hyperactivity in healthy subjects ; Circulatory System ; Qualitative platelet defects PRIMARY OUTCOME: Platelet aggregation in response to optimised adenosine diphosphate (ADP) agonist concentration, measured using light transmission aggregometry at baseline and 24 h SECONDARY OUTCOME: Thrombin generation capacity measured by fluorogenic substrate generation at baseline and 24 h INCLUSION CRITERIA: 1. Male subjects 2. No history of cardiovascular disease 3. Aged =30 years 4. Normal haemostatic measurements 5. Normal platelet aggregation response to adenosine diphosphate (ADP) agonist 6. Not taking any supplements or medications known to affect platelet function, without a suitable washout period