A randomised clinical trial assessing the additional value of ovarian hyperstimulation in intrauterine insemination (IUI) for couples with an abnormal post-coital test (PCT)

INTERVENTION: These couples were randomly allocated to three cycles of IUI with COH or three cycles of IUI without COH. Controlled ovarian hyperstimulation as well as ovulation detection induction, semen preparation and insemination regimens were performed according to hospital‐specific protocols. CONDITION: Subfertility ; Pregnancy and Childbirth ; Subfertility PRIMARY OUTCOME: The primary endpoint was ongoing pregnancy within three cycles of IUI. Ongoing pregnancy was defined as the presence of foetal cardiac activity at transvaginal sonography at a gestational age of at least 12 weeks. SECONDARY OUTCOME: Secondary endpoints were total number of clinical pregnancies, miscarriages and multiple pregnancies. INCLUSION CRITERIA: Couples were eligible if they had an abnormal PCT, either due to cervical hostility diagnosed by a well‐timed, non‐progressive PCT with normal semen parameters or due to a poor semen quality. The spontaneous pregnancy chance in the next year, leaving the result of the PCT out of consideration, was less than 30%.