A randomly controlled comparison of risperidone added with intramuscular clonazepam in the treatment of excitement of schizophrenia

To study the efficacy and safety of risperidone added with intramuscular clonazepam in the treatment of excitement of schizophrenia. METHOD: Subjects were inpatients aged 18～50 who met the ICD 10 criteria for schizophrenia or schizophrenia form disorder with a sore of 60 or higher on the Positive and Negative Synptoms Scale (PANSS) and were randomly divided info three groups. Efficacy and side effects were evaluated with CGI, PANSS and TESS, respectively. RESULTS: Risperidone combined intramuscular clonazepam was as effective as haloperidol and clozapine in the treatment of excitement of schizophrenia. CONCLUSION: Risperidone combined intramuscular clonazepam was effective and safe to control acute excitement and less side effects.