CAPITAL OFFLOAD-SHOCK

The trial will evaluate the in‐hospital mortality between starting renal replacementtherapy (RRT) immediately upon confirmation of eligibility and consent and using standardmedical therapy without RRT unless one of the following occurs: 1) clinical volumeoverload refractory to diuresis with high‐dose intravenous furosemide plus eitherthiazide‐like diuretic and/or acetazolamide, resulting in pulmonary edema, necessitationventilation with FiO2 > 50%, 2) hyperkalemia with serum potassium >6mmol/L, or 3) severemetabolic acidosis with pH <7.20 and bicarb <=12 mmol/L thought to be due to renalinsufficiency.