Efficacy of Thymus Vulgaris Mouthwash in the Management of Biofilm-Induced Gingivitis

Authors
Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2026
The goal of this clinical trial is to learn whether a mouthwash made from thyme (Thymus vulgaris in its scientific name) helps improve gum health in people with plaque-induced gingivitis. The mouthwash will be compared with Chlorhexidine mouthwash and a placebo (a mouthwash that does not contain the active ingredient being tested). The main questions this study aims to answer are: * Does Thymus vulgaris mouthwash improve gum health and lower plaque buildup and gum bleeding? * Does it change the levels of substances in saliva linked to gum inflammation and tissue damage? * What side effects do participants experience, and how do they rate their experience with the mouthwash? Participants will be randomly assigned to one of three groups: Thymus vulgaris mouthwash, 0.12% Chlorhexidine mouthwash, or placebo. They will: * Rinse with 10 mL of their assigned mouthwash twice daily for one minute each time. * Have their gum health checked at the start of the study, after two weeks, and after one month. * Provide saliva samples at each visit for testing. * Report any side effects and share their experience with the mouthwash. To help ensure a fair comparison, the mouthwashes will be provided in identical containers with coded labels. Neither participants nor the examiner will know which mouthwash each participant receives until the study is completed and the results are analyzed.
Epistemonikos ID: 71c3075c5b2849f0b7f37ad2801f47f87f86bfcf
First added on: Oct 30, 2026