Application of Berberine in the secondary prevention of ischaemic stoke: a multi-center, double-blind, randomized, placebo-controlled trial

INTERVENTION: Group B:Berberine 0.5 g, orally taken three times daily and Atorvastatin 10mg once daily and Aspirine 0.1 g once daily for 1 year ;Group P:Placebo 0.5 g, orally taken three times daily and Atorvastatin 10mg once daily and Aspirine 0.1 g once daily for 1 year ; CONDITION: ischaemic stoke PRIMARY OUTCOME: Rate of cardiovascular events;Incidence of peripheral arteries diseases;Recurrence rate of stroke in 1 year; SECONDARY OUTCOME: Serum triglyceride and cholesterol, low density lipoprotein concentration; INCLUSION CRITERIA: 1. male and female aged 35 to 75 years old; 2. patients with symptomatic cerebral infarction in the previous 2 weeks to 3 months; 3. patients with focal signs that had lasted >=24 hours and ischemic infarction‐related focal lesion compatible with their signs and symptoms defined by computed tomography or magnetic resonance imaging; 4. patients provided written, informed consent; 5. patients with one or more risk factor for cerebrovascular disease that can be treated.