Droperidol vs Ondansetron in Nausea Treatment in the Emergency Department (DONuT)

INTERVENTION: Droperidol 2.5mg intravenously. One dose only. Participants will be randomised into intervention or control group. Once the participant has been allocated to the intervention group, the treating physician will chart the intervention on the electronic medication chart and the intervention will be given by the treating nurse, which will be subsequently logged. Fidelity will be monitored by review of the electronic medication chart within the electronic medical record ‐ which will document the time when the intervention was administered. CONDITION: Emergency medicine ‐ Other emergency care nausea; ; nausea Oral and Gastrointestinal ‐ Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon PRIMARY OUTCOME: Proportion of participants with a change in nausea of 5 mm or greater on a visual analog scale.[30 minutes post‐treatment] SECONDARY OUTCOME: Comparison of mean change in nausea between groups on a Visual Analog Scale.[30 minutes post‐treatment] Comparison of patient centered outcome between groups, as response to the question “The medicine I received had the desired effect for meâ€?, Yes or No[30 minutes post‐treatment] Description of adverse events for all groups. Absence or presence (mild/moderate/severe) of headache or dizziness will be specifically noted. Agitation or sedation will be rated on the Richmond Agitation‐Sedation Scale. Any other adverse events will be noted as free text.[From 30 minutes post‐treatment to conclusion of ED episode of care.] INCLUSION CRITERIA: Emergency Department patients aged 18 years or more, with nausea and/or vomiting as a primary or secondary complaint (any underlying cause).