Smart Scaffolds, Stronger Smiles Smarter Healing: AI-Boosted Multiphasic Scaffold Design for PDL Regeneration

The periodontal ligament is vital for tooth support, and its loss, frequently resulting from periodontitis, trauma, or endodontic lesions, presents a significant clinical challenge; global cases of severe periodontitis increased by 91.54% from 1990 to 2021. Conventional monophasic scaffolds offer a uniform environment, limiting their efficacy in regenerating complex, multi-tissue structures like the periodontium. This study introduces an AI-enhanced, 3D multi-phasic scaffold to precisely restore the periodontal apparatus and overcome the limitations of non-uniform tissue growth seen in some multiphasic designs. The methodology involved sequential steps: high-resolution CBCT and intraoral scans to capture defect geometry; precise defect mapping to define the Target Regeneration Volume; and AI Mesh mixer implementation to generate three distinct, seamlessly graded lattice zones. This AI-driven design ensures Optimal Biomechanics (Precision) by perfectly matching the scaffold\'s stiffness to native tissue, thereby eliminating stress-shielding.