A study to investigate the preventive effect of AG-1749 against the onset of gastric and duodenal ulcers that can be seen during long-term treatment with nonsteroidal anti-inflammatory drugs (NSAID).

INTERVENTION: Intervention name : AG‐1749 (Lansoprazole) Dosage And administration of the intervention : Oral CONDITION: Patients that require long‐term NSAID treatment to manage pain. PRIMARY OUTCOME: Frequency of gastric or duodenal ulcer INCLUSION CRITERIA: 1) The patient was on NSAID treatment on the day when consent was obtained, and requires the long‐term continuous treatment even after treatment with the investigational drug is started. 2) The patient was confirmed to have a history of gastric ulcer or duodenal ulcer (combined gastric and duodenal ulcer is also possible).