Hepatic Mitochondrial Metabolism in Fatty Liver Disease in Humans

Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2024
The goal of this clinical trial is to investigate in healthy volunteers the mechanisms by which ethanol and lipids, the two key risk factors of steatotic liver disease (SLD), affect liver mitochondrial metabolism. The main question it aims to answer is: • Does acute administration of ethanol and lipids increase hepatic mitochondrial reductive stress as determined by orally ingested stable isotope tracer 13C-alpha-ketoisocaproate and by plasma beta-hydroxybutyrate to acetoacetate ratio (b-OHB/AcAc) in humans?
Epistemonikos ID: 703f73de8c12fb0c68bc694659003bb7535d1d1c
First added on: Sep 01, 2024