Anphotericin B deoxicolate, therapeutic experience in meningeal cryptococcosis in a VIH adult patients of Carlos Van Buren Hospital

Amphotericin B is a antifungal drug widely used in systemic infections by filamentous and levaduriform fungi, as in meningitis by Cryptococcus neoformans. Its adverse reactions can be immediate or dose and time dependent. In our paper, 27 patient files were reviewed in C. van Buren hospital of Valparaíso and all of them met the criteria for inclusion (24 men and 3 women). In 96.3 percent of cases, headaches were the main symptom of meningitis caused by Cryptococcus. Twenty five cases were confirmed by the use of chinese ink and/or by culture. During the treatment with amphotericin B, the most frequent changes were hypokalemia (83 percent) and nefrotoxicity in 59.1 percent. The average of cumulative dose administered was 525 mg and was suspended when a clinical recovery was achieved next to a sterile cefalorraquid liquid (negative to chinese ink and/or culture). 33.3 percent of the patients diagnosed with meningitis by C. neoformans died due to different complications.