Arzneimittel-Forschung

Compared the chemically and pharmacologically similar substances doxepin and amitriptyline in a double-blind trial with 20 patients. Clinical and statistical analyses showed great similarity between the substances. Remissions were effected in 1/2 of the Ss. Antidepressive and sedative effects were equally strong. Chronic depressions were not influenced as well by doxepin as acute ones. The side effects of doxepin are a result of its anticholinergic property and of no special damage to the S. Changes of the serum transaminases and the alkalic phosphatase during treatment should be noted. (24 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)