Feasibility study of lidocaine for peripheral venous pain induced by oxaliplatin

INTERVENTION: Lidocaine will be administrated continuous IV in parallel with oxaliplatin. CONDITION: colorectal cancer PRIMARY OUTCOME: To evaluate feasibility and to determine the recommended dose SECONDARY OUTCOME: The degree of venous pain; Blood concentration of lidocaine : pharmacokinetics INCLUSION CRITERIA: 1. Histologically proven adenocarcinoma of colorectal cancer. 2. Be to administered of more than 100 mg per sqm of oxaliplatin via peripheral vein. 3. Able to be cutdown in 22G indwelling needle in the elbow or forearm 4. Age: 20 years to 75 years 5. PS(ECOG) 0‐1 6. Adequate main organ functions 7. Written informed consent by the participant