Randomized trial of transbronchial biopsy with or without navigation by virtual bronchoscopy using X-ray fluoroscopy and endobronchial ultrasonography with guide-sheath (BUS-GS) for pulmonary peripheral small lesions

INTERVENTION: With navigation by virtual bronchoscopy Without navigation by virtual bronchoscopy CONDITION: pulmonary peripheral small lesions PRIMARY OUTCOME: Yield (Diagnostic rate) SECONDARY OUTCOME: 1)The time to reach the lesion; 2)The time of first biopsy; 3)The time of X‐ray fluoroscopy; 4)The time of total examination ; 5)Difference between bronchi by virtual bronchoscopy and actual bronchi; 6)Bronchial generation inserted by bronchoscopy; 7)Complication; 8)Patient suffering by bronchoscopy INCLUSION CRITERIA: 1.Pulmonary peripheral small lesions of ≤ 20 mm deemed, but not determined, as lung cancer 2.Not visible by bronchoscopy 3.20 or more than 20 years of age 4.SpO2 90 or more than 90% 5.Written informed consent