Effect of benzyl-nicotinate on wound infection in surgical patients

INTERVENTION: A topical cream containing benzyl nicotinate will be applied on the site of planned surgical incision. This molecule has a distinct vasodilative effect peaking at the 10th minute of application which lasts about 45 minutes. The cream which contains benzyl nicotinate also contains etofenamate; an antiinflammatory agent. The cream is placed in a syringe with the needle removed. The cream is applied to the incision with a dose of 1 mg benzyl nicotinate applied to each cm of the wound (1 ml cream/10 cm). The cream is applied on the operating table on the planned incision. The necessary amount will be distibuted homogenously on the planned incision with a width of 1 cm. Then the skin is prepared and draped. The surgery goes on as usual. The observation period is 30 postoperative days. CONDITION: Surgical site infection PRIMARY OUTCOME: Surgical site infection. This will be assessed by monitorization of the health care professionals. If the wound is opened microbiological culture assessment will be done additionally. SECONDARY OUTCOME: All cause mortality. This will be assessed by health care professionals if the patient is still hospitalized. If the patient is discharged within the time frame of the study the patient will be invited for clinical examination. If this is not possible the patient will be contacted by telephone. INCLUSION CRITERIA: All general surgical patients needing a skin incision.