Nasal Continuous Positive Airway Pressure-Assisted Neonatal Oral-Endotracheal Intubation: Protocol for a Randomized Controlled Trial

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Standard care group:standard care;nCPAP group:nasal Continuous Positive Airway Pressure‐assisted neonatal oral‐endotracheal intubation; CONDITION: Respiratory failure requiring intubation PRIMARY OUTCOME: the magnitude of SpO2 decline during first intubation; SECONDARY OUTCOME: Incidence of bradycardia (HR<100 bpm) during the first intubation attempt;Duration of bradycardia (HR <100bpm) during first intubation attempt (seconds);Total duration of all intubation attempts (successful and unsuccessful) (seconds);Time to bradycardia (HR <100bpm) during the first intubation attempt (seconds);Duration of desaturation (SpO2 < 90%) during first intubation attempt (seconds);Number of intubation attempts;Incidence of first intubation attempt success;Time to desaturation (SpO2 < 90%) during the first intubation attempt (seconds);Duration of the first intubation success (seconds);Incidence of desaturation (SpO2 < 90%) during the first intubation attempt; INCLUSION CRITERIA: 1.Receiving non‐invasive respiratory support; 2.Undergoing non‐emergency oral endotracheal intubation in the NICU; 3.The guardian agrees.
Epistemonikos ID: 6c2d92487f2030927c16cd36e08112b8b9afedc3
First added on: Jul 21, 2026