The impact on glycemic control through progressive resistance training with bioDensity™ in Chinese elderly patients with type 2 diabetes The PReTTy2 (Progressive Resistance Training in Type 2 Diabetes) Trial

Aims: To evaluate the effects of a novel, low-volume, high-intensity Progressive Resistance Training (PRT) technique on blood glucose control in elderly Chinese patients with Type 2 Diabetes. Materials and methods: The PReTTy2 trial enrolled 300 male and female patients with Type 2 Diabetes in a randomized resistance training program with the bioDensityTM technique. 100 were control patients with no training intervention and 200 had resistance training. Anthropometry, biochemical parameters, HbA1c and fasting plasma glucose (FPG) were measured at baseline, 3-month and 6-month intervals. Results: 265 patients completed the study with no adverse events. There were no statistically significant differences in HbA1c for all patients, control and PRT groups, at baseline (p = 0.60), 3 months (p = 0.42) and 6-months (p = 0.45). Subgroup analysis with baseline HbA1c > 7.5% (58 mmol/mol), showed statistically significant differences in HbA1c and FPG between groups at 6 months (p < 0.05). All PRT group patients had statistically significant differences from baseline at 6 months for HDL (1.25 + 0.32 vs. 1.17 + 0.26 mmol/L, p < 0.001), LDL (3.23 +/- 0.89 vs. 2.93 +/- 0.80 mmol/L, p < 0.001) and total cholesterol (4.97 +/- 1.22 vs. 4.58 +/- 1.03 mmol/L, p < 0.001). Conclusions: PRT improves glycemic indices in elderly patients with Type 2 Diabetes with poor glucose control as an adjunct to diet and medication. Progressive Resistance Training with bioDensityTM is feasible, safe and effective in elderly patients with Type 2 Diabetes. (C) 2019 Published by Elsevier B.V.