Comparison of short course (24hours) versus long course prophylactic antibiotic regimen following caesarean section: an Open Label Randomized Control Trial

Authors
Category Primary study
Registry of TrialsPan African Clinical Trials Registry
Year 2026
INTERVENTION: long course prophylactic antibiotic short course 24 hours prophylactic antibiotic CONDITION: ; Pregnancy and Childbirth Pregnancy and Childbirth PRIMARY OUTCOME: The primary outcome is the incidence of postoperative infections, comprising surgical site infections (SSIs), endometritis, and urinary tract infections (UTIs), assessed within 30 days of surgery. SECONDARY OUTCOME: The secondary outcome is the need for additional therapeutic antibiotic use following caesarean section, assessed and compared between the two groups. This will be measured by documenting any prescription of antibiotics beyond the allocated study regimen during the 30‐day postoperative period, whether initiated during the inpatient stay or at any follow‐up contact point. INCLUSION CRITERIA: 1.Pregnant woman with a confirmed indication for either elective or emergency caesarean section. 2.Gestational age of 28 weeks or greater. 3.Carrying a live singleton or multiple pregnancy. 4.Able and willing to provide written informed consent to participate in the study. 5.No clinical or laboratory evidence of preoperative infection at the time of enrolment. 6.Has not received systemic antibiotic therapy within 60 minutes before surgery, except for the routine preoperative prophylactic antibiotic administered according to the study protocol.
Epistemonikos ID: 6b83562961f796966d8a7543213751336c4be5da
First added on: Oct 08, 2026