Can Advanced-Platelet Rich Fibrin (A-PRF), a patient blood-derived living biomaterial, prevent chronic inflammation after wisdom tooth surgery?

INTERVENTION: The test group will undergo third molar removal plus the application of Advanced Platelet‐Rich Fibrin (A‐PRF) on the alveolar socket. The control group will receive the same procedure but with natural healing (without the use of any biomaterial). Randomisation process: Participants will be randomized to test or control treatment (PRF versus no‐PRF) based on computer‐generated random codes. The allocation will be hidden from the surgeon by opaque envelopes to be opened right before the surgical procedure. With the exception of the placement of PRF or not, procedures will be similar for both groups. Patients will be followed up for 1 month after surgery. CONDITION: Systemic acute inflammatory response after wisdom tooth removal in otherwise healthy patients ; Oral Health ; Systemic Inflammatory Response Syndrome of non‐infectious origin without organ failure PRIMARY OUTCOME: Acute inflammatory response measured by hs‐C‐reactive protein serum levels at 24 h after intervention SECONDARY OUTCOME: There are no secondary outcome measures INCLUSION CRITERIA: 1. Two unilateral fully impacted mandibular third molars which have the same degree of surgical difficulty comparing one side with the other 2. Healthy patients without significant medical diseases or a history of bleeding problems 3. Adequate level of plaque control (plaque index (PI) <15%) 4. Non‐smokers patients 5. Able to give written consent