Effectiveness and safety of bronchial thermoplasty-A multicenter study in Japan

INTERVENTION: bronchial thermoplasty(3 times every 3 weeks) CONDITION: Severe asthma PRIMARY OUTCOME: QOL (quality of life)(at 3M,6M,and 12M) SECONDARY OUTCOME: Asthma exacerbation; Emergency room visits; Unscheduled physician office visits; Hospitalization frequency; Hospitalizations; Days missed from work/school; Physician's Global Evaluation of Treatment Effectiveness (GETE) assessment; Therapeutic drug use; Pulmonary function; Adverse events; (at 3M,6M,and 12M) INCLUSION CRITERIA: 1. Uncontrolled severe asthma patients treated with high dose inhaled corticosteroid and long‐acting beta2‐agonists. 2. Eligible for fiberoptic bronchoscopy.