For postoperative body fluid management and postoperative complication prevention Torbaptan's effectiveness

Authors
Category Primary study
Registry of TrialsJapan Primary Registry Network
Year 2023
INTERVENTION: Tolvaptan Sodium Phosphate injection , Azosemid , loop diuretic Usual treatment group) Azosemide tablet + loop diuretic (physician's choice) study drug administration group) Azosemide tablets + tolvaptan injection CONDITION: Patients receiving Open Heart Surgery PRIMARY OUTCOME: Cumulative urine volume 1‐2 days after surgery SECONDARY OUTCOME: Presence or absence of postoperative complications; ‐electrolyte abnormality; ‐atrial fibrillation; ‐acute renal failure; ‐postoperative death ; Time until postoperative complications weight change; ‐Weight loss on the 1st and 2nd days after surgery; ‐Days to return to preoperative body weight; Change of urine volume; Daily urine volume on the 2nd, 3rd and 4th days after surgery; Drug doses on postoperative day 4 and until hospital discharge (postoperative day 10‐14 or discharge, whichever comes first); ‐Torvaptane; ‐Catecholamine; ‐Other diuretics; ‐Basic infusion; Artificial respiration management period; ICU stay period; All hospitalization period INCLUSION CRITERIA: 1) Patients planning to perform open heart surgery under a heart‐lung machine 2) Patients who are aged 20 or older when acquiring consent 3) Patients who have obtained document consent with their own freedom after fully understood participation in this research
Epistemonikos ID: 69d0b2e753f20799082e3fcc161eab6c215553e7
First added on: Aug 26, 2024