Local Endometrial Trauma (LET) in Patients with Recurrent Implantation Failure

INTERVENTION: Local Endometrial Trauma (LET), a randomised timed Pipelle endometrial biopsy. This would be done in the mid‐luteal phase in the month immediately preceding the IVF treatment. CONDITION: Recurrent implantation failure PRIMARY OUTCOME: Clinical pregnancy (i.e. the prescence of fetal heart activity as seen on transvaginal ultrasound approxiamtely four weeks after embryo transfer). SECONDARY OUTCOME: Endometrial tissue collected during the LET will be analysed for markers of successful implantation such as activin A, activin B, follistatin and their receptors. Pregnancy outcome up to delivery. Seen by regular pregnancy monitoring such as ultrasound, blood pressure testing and urine testing. The effect of the LET procedure on positive serum HCG pregnancy test two weeks after embryo transfer INCLUSION CRITERIA: Patients about to undergo a cycle of IVF/ICSI treatment involving fresh embryo transfer, who has a history of recurrent implantation failure in IVF/ICSI treatment.