Investigating the effect of Casein Phosphopeptide -Amorphous Calcium Phosphate with Fluoride on caries prevention

INTERVENTION: As a crossover study, patients in the first group receive the medication ‐ MI paste plus ‐ containing casein phosphopeptide ‐ amorphous calcium phosphate and Fluoride. A pea‐sized amount of the paste is applied to the teeth each night after routine brushing. This regimen is continued for one month As a crossover study, patients in the second group receive the placebo paste first. The placebo is also a paste but devoid of any active ingredient. A pea‐sized amount of the paste is applied to the teeth each night after routine brushing. This regimen is continued for one month. Intervention 1: As a crossover study, patients in the first group receive the medication ‐ MI paste plus ‐ containing casein phosphopeptide ‐ amorphous calcium phosphate and Fluoride. A pea‐sized amount of the paste is applied to the teeth each night after routine brushing. This regimen is continued for one month. Intervention 2: As a crossover study, patients in the second group receive the placebo paste first. The placebo is also a paste but devoid of any active ingredient. A pea‐sized amount of the paste is applied to the teeth each night after routine brushing. This regimen is continued for one month. Treatment ‐ Drugs CONDITION: Caries limited to enamel. ; White spots (Initial caries) White spots (Initial caries) PRIMARY OUTCOME: Plaque pH. Timepoint: Before and after each paste use. A total of 4 measures with one month intervals. Method of measurement: pH test strips. Salivary pH. Timepoint: Before and after each paste use. A total of 4 measures with one month intervals. Method of measurement: pH test strips. INCLUSION CRITERIA: INCLUSION CRITERIA:Patients receiving fixed orthodontic treatment and over 12 years of age. Between 3 and 12 months of their orthodontic treatment should have commenced. Exclusion criteria: Taking medications; systemic diseases; pregnancy; loss/missing of first permanent molars; using mouthwashes.