Peripartum depression and anxiety in mothers expecting uncomplicated twin infants – an antenatal model of care in the North East of England

Mothers of twin infants have a two-fold increased risk of postnatal depression (PND). We hypothesised that an antenatal midwife-led support intervention would reduce PND at 26 weeks. One hundred and sixty-two mothers expecting uncomplicated twins were randomised to twin intervention (TI) or twin control (TC). Each TC case was matched with a singleton control (SC). A postal questionnaire, incorporating the EPDS and HADS-A was sent pre-intervention and at three time points after delivery. Response rates were > or = 80%. The study did not detect a difference between groups in depression or anxiety mean score or ‘categorical cut-off’ at any time point.