Galileo trial

INTERVENTION: ‐ GDFT ‐ Low CVP CONDITION: Liver tumor, Surgery, Fluid management ; ; PRIMARY OUTCOME: ‐ Total intraoperative blood loss SECONDARY OUTCOME: ‐ Need for blood, plasma or platelet transfusion ; ; ‐ Duration of liver resection phase ; ; ‐ Duration of Pringle maneuver ; ; ‐ Duration of the total operation ; ; ‐ Liver blood volume as measured by contrast enhanced ultrasound (CEUS) ; ; ‐ Fluid balance at the end and 24 hours after surgery ; ; ‐ Given fluid on ward ; ; ‐ Vasopressor use ; ; ‐ Time spent above target SV ; ; ‐ The ability of surgeons to estimate to which group the patient is randomized ; ; ‐ Kidney function after 0, 24 and 48 hours ; ; ‐ IL‐6 at 0, 24, 48 hours ; ; ‐ RAAS system (aldosterone, renine, ADH in plasma, electrolytes), urine: 24‐hours urine sample for sodium, potassium and creatine excretion, pre‐op, 24, 48h and 5 days ; ; ‐ Outcome data: all complications ; ; ‐ Daily body weight and ankle & abdominal girth ; INCLUSION CRITERIA: Adult patients, undergoing open liver resection and which are able to provide written informed consent