An rct: To evaluate the clinical characteristics of patients having spinal anaesthesia with intrathecal bupivacaine and clonidine, as well as intrathecal bupivacaine and fentanyl

Aim: The aim of this study to assess the clinical profile of patients undergoing spinal Anesthesia with intrathecal bupivacaine with clonidine and intrathecal bupivacaine with fentanyl. Methods: A prospective double blind randomized controlled study was conducted in the Department of anaesthesiology, Katihar medical college Hospital, Katihar, Bihar, India. for 1 year. 110 adult patients were randomly divided on an alternative basis into two groups of 55 each. Group “A”‐Bupivacaine plus clonidine group. Group “B”‐Bupivacaine plus fentanyl group. Patients with ASA grade 1 and 2 patients and age group of 18‐72 yrs. Those patients scheduled to undergo elective lower abdominal, lower extremity, gynaecological or urological surgeries under subarachnoid block were included in this study. Patients belonging to group ‘A’ received 3 ml (15 mg) of hyperbaric bupivacaine 0.5% plus 1 µg.kg‐1 of clonidine. Patients of group ‘B’ received 3 ml (15 mg) of hyperbaric bupivacaine 0.5% plus (25 µg) of fentanyl. After injection, patient was immediately turned to supine position.Results: Majority of patients in the both the groups belonged to thegroup 30 to 40 years 34.54%. The number of males 43.64% and females 56.36%. Majority of female patients in the both the groups belonged to the group 160 to 170 cms and males 171 to 175 cms, Samples were height matched. Most of the patients 41.82 percent from gynaecology surgery followed by lower limb surgery 33.63 percent and Lower Abdominal Surgery 24.55 percent. Conclusion: We concluded that the administration of local anaesthetics in combination with opioids intrathecally is an established technique for managing postoperative pain following abdominal, pelvic, thoracic or orthopaedic procedures on lower extremities. Local anaesthetics with opioids demonstrate significant synergy.