Detection of the plasmid-mediated quinolone resistance determinants in clinical isolates of Acinetobacter baumannii in China.

We examined the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants among Acinetobacter baumannii in Anhui, China. And β-lactamase genes and mutations in quinolone resistance-determining regions (QRDRs) were also investigated among the PMQR-positive isolates. Among the 39 A. baumannii isolates, 3 (7.7%) isolates harbored qnrB and 1 (2.6%) harbored qnrS. Mutations in the QRDRs of gyrA were identified in 2 isolates amongst the 4 PMQR-positive isolates. Quinolone resistance could be transferred by conjugation from all 4 PMQR-positive donors. In conclusion, more attention should be taken to prevent the transmission of PMQR genes among A. baumannii.