Can Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?

Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2014
The purpose of this study is to examine whether two clinically sensible dose regimen of fentanyl (low dose vs. high dose) lead to different pain scores as measured by the nonverbal rating scale (NRS) in healthy volunteers at 4.5 to 6.5 hours after fentanyl application. Pain modalities tested will include transdermal electrical stimulation and cold pressor pain. The investigators hypothesize that the high dose fentanyl group will have an increase of approximately 20% in the NRS.
Epistemonikos ID: 65d7094f26932dc973ae25701af5fb70a3ec401c
First added on: May 12, 2024