Effect of early urate-lowering therapy on artery stiffness in hypertensive patients with asymptomatic hyperuriacemia: a random, open clinical trial

INTERVENTION: control group:anti‐hypertension and lifestyle change;invention group:anti‐hypertension and lifestyle change + benzbromarone; CONDITION: hypertension with asyptomatic hyperuricemia PRIMARY OUTCOME: artery stiffness parameter; SECONDARY OUTCOME: systolic blood pressure;diastolic blood pressure;CIMT; INCLUSION CRITERIA: 1. participants with age between eighteen to sixty years old, male or female; 2. body mass index < 33 kg/m2; 3. without treatment,or mild‐to‐moderate hypertension subjects with anti‐hypertensive agents (SBP 140 to 180mmHg and DBP 90 to 110mmHg); 4. serum uric acid level > 420 umol/L (7 mg/dL); 5. participants must sign informed consent; 6. type of uric acid discharge poor: uric acid drainage less than 0.48 mg/kg/h, uric acid clearance (Cua, urinary uric acid * every minute urine volume/serum uric acid) < 6.2 ml/min. the Cua/Ccr ratio < 5%.