Microemulsion Gel containing Sea Holly Extract for Post Acne Erythema Reduction

Authors
Category Primary study
Registry of TrialsThai Clinical Trials Registry
Year 2026
INTERVENTION: Active Comparator Other,Placebo Comparator Other Sea Holly Extract gel,Placebo gel Sea Holly is a Thai herbal medicine from the Acanthaceae family, normally found in the northern part of Thailand. Sea holly extract can inhibit inflammatory cytokines such as interleukin families and MMPs. It also promotes collagen formation and enhances the wound healing process. This gel requires twice a day application.,An identical placebo consists of deionised water, peppermint polyglyceryl 10 laurate and hexanediol, without the active ingredient. This gel requires twice a day application. CONDITION: Acne vulgaris; Post‐inflammatory erythema Post‐acne erythema ; Acne vulgaris; Post‐inflammatory erythema PRIMARY OUTCOME: Investigator Global improvement scale 5 ordinal scale between 0‐4 SECONDARY OUTCOME: Adverse effect 4 Ordinal scale from 0‐4,Time to acne redness recovery period 5 Days,Clinician erythema assessment scale 5 Ordinal scale 0‐3,Erythema inde Xby mexameter measurement 5 numeric score,Melanin inde Xby mexameter measurement 5 numeric scale,Patient satisfaction score 1 Likert scale 5 scores INCLUSION CRITERIA: Age between 18 and 50 years Male or female se X Post‐acne erythema in both cheeks Severity grading of post‐acne erythema using Clinician Erythema Assessment Scale (CEA) criteria grade 2 or higher
Epistemonikos ID: 652f9ef55c6d6b8e8a61d9cd393d76333dafee49
First added on: Aug 08, 2026