Core symptoms of posttraumatic stress disorder unimproved by alprazolam treatment.

Authors
Category Primary study
JournalThe Journal of clinical psychiatry
Year 1990
The authors report a random-assignment, double-blind crossover trial comparing alprazolam and placebo in posttraumatic stress disorder (PTSD). Ten patients fulfilling DSM-III criteria for PTSD completed 5 weeks of treatment on each agent. Improvement in anxiety symptoms was significantly greater during alprazolam treatment but modest in extent. Symptoms specific to PTSD were not significantly altered. The impact of nonspecific symptomatic effects on the outcome of drug trials in PTSD is considered.
Epistemonikos ID: 62e26c9664156cae55ea7ffec9196cbf8e4900f8
First added on: Nov 24, 2012