Dutch Intraventricular Thrombolysis in Cerebral Haemorrhage study

INTERVENTION: External ventricular drain(s) (EVD) placement. Infusion of 3 mg tr‐PA through the EVD twice daily with a maximum of six days, compared to extraventricular drainage alone. CONDITION: Intraventricular haemorrhage, intracerebral haemorrhage ; Circulatory System ; Intracerebral haemorrhage PRIMARY OUTCOME: Poor outcome at three months (mRankin scale and GOS). SECONDARY OUTCOME: 1. Drain dependency at 3 months; 2. Amsterdam Linear Disability Scale score at 3 months; 3. Intraventricular or parenchymal bleeding complications; 4. Ventriculitis INCLUSION CRITERIA: 1. Age >18 years 2. IVH caused by extension of spontaneous ICH confirmed by computed tomography (CT) scan 3. Glasgow Coma Score on admission of <14 4. Able to include patients within 48 hours after ICH onset 5. Historical mRankin of 0 or 1