Acupuncture for treatment of knee osteoarthritis: immunological view

INTERVENTION: Two groups receive verum (real) acupuncture either with manual manipulation, or with electro‐acupuncture, and the third sham (control) acupuncture. CONDITION: Knee osteoarthritis (OA) ; Musculoskeletal Diseases ; Arthritis PRIMARY OUTCOME: Western Ontario and McMaster Universities Arthritis Index (WOMAC) scale SECONDARY OUTCOME: Immunological study for adhesion molecules such as intercellular adhesion molecule 1 (ICAM1) and cytokines such as interleukin‐1beta (IL1B) and Tumor Necrosis Factor (TNF) alpha, before and after treatment. INCLUSION CRITERIA: Patients are included if they: 1. Agreed to participate in the study by written, informed consent 2. Fulfilled the American College of Rheumatology criteria for knee OA