A comparative study of ultrasound-guided microwave ablation and parathyroidectomy in the treatment of primary hyperparathyroidism:A randomized controlled study

INTERVENTION: Group 2:Ultrasound‐guided Microwave Ablation;Group 2:parathyroidectomy; CONDITION: Primary Hyperparathyroidism PRIMARY OUTCOME: iPTH;Serum calcium;Serum phosphate;ALP;Vitamin D; INCLUSION CRITERIA: 1. Symptomatic patients; 2. Asymptomatic patients with one of the following situations: (1) An increase in serum calcium>0.25 mmol/L above the upper limit of normal; (2) Patients younger than 50 years of age; (3) Patients with a T‐score <‐2.5 at the lumbar spine, total hip, femoral neck, or distal 1/3 radius or those with a significant reduction in bone mineral density (BMD) and/or increased risk of fragility?fracture; (4) Patients with a reduction in creatinine clearance less than 60 ml/min; (5) Patients who were unable or unwilling to comply with observation protocols; 3.At least one parathyroid nodule clearly showed on US and accessible for MWA; 4.Increased 99 mTc‐sestamibi(MIBI) radionuclide concentration in both the early and delayed phases; 5.No recurrent laryngeal nerve impairment confirmed by laryngoscopy in patients with a voice change following previous PTX.