A single-center, double-blind, randomized, placebo-controlled clinical study on the effects of postbiotics on oral health status, oral inflammation, and oral microbiota in a diabetic and orally frail population.

INTERVENTION: Placebo group:Diabetic and orally frail population receiving placebo;Intervention Group 1:Healthy adults using postbiotic toothpaste;Intervention Group 2:Diabetic and orally frail population using postbiotic toothpaste; CONDITION: Diabetes mellitus accompanied by symptoms of oral frailty PRIMARY OUTCOME: Oral microbiome; INCLUSION CRITERIA: 1.Male or female diabetic volunteers, aged 20 to 80 years; diagnosed with oral frailty according to the Oral Frailty Index‐8 criteria. 2.During the trial period, participants agree not to take any oral probiotics, postbiotics, or oral products or supplements with similar functional claims that may disrupt the oral microbiota or affect the evaluation of the trial outcomes. 3.Willing to not participate in any other interventional clinical studies during the trial period. 4.Able to fully understand the nature, purpose, potential benefits, as well as the possible risks and side effects of this study. 5.Willing to comply with all study requirements and procedures. 6.Sign the informed consent form. Male or female diabetic volunteers, aged 20 to 80 years; diagnosed with oral frailty according to the Oral Frailty Index‐8 criteria.