A Double-blind, Randomized Controlled Clinical Study on the Intervention of Cognitive Impairment in Cerebral Small Vessel Disease by Wen Shen Yi Zhi Formula (a traditional Chinese medicine)

Authors
Category Primary study
Registry of TrialsInternational Traditional Medicine Clinical Trial Registry
Year 2026
INTERVENTION: Intervention Group:Kidney‐tonifying and intellect‐enhancing formula;Control Group:Placebo; CONDITION: Cerebral small vessel disease PRIMARY OUTCOME: Change in Montreal Cognitive Assessment scores compared to baseline.; SECONDARY OUTCOME: MMSE Score;VaDAS‐Cog Score;ADL score;CDR‐SB Scale;TMT Rating;CDT Rating;NPI Scoring;TCM syndrome score; INCLUSION CRITERIA: (1) Meets the diagnostic criteria for cognitive impairment due to small vessel disease of the brain; (2) Meets the diagnostic criteria for deficiency of kidney yang with stasis in the meridians; (3) Hachinski ischemia score =7 points; (4) 16 = Montreal Cognitive Assessment (MoCA) =26; (5) Clinical Dementia Rating (CDR) =2 points; (6) Aged 40‐85 years, gender unrestricted; (7) Able to cooperate with trial examinations; (8) The volunteer subject and their guardian have signed the informed consent form.
Epistemonikos ID: 620b18edf2f09793dad61a7cb18815ade3ecc907
First added on: Aug 08, 2026