Application potential of therapeutic ultrasound in oral diseases.

PURPOSE: To review the literature on the application potential of ultrasound in the treatment of various oral and dental diseases. METHODS: Two reviewers carried out a computer-based literature search using PubMed and Web of Science to identify papers published up to February 2025. The keywords used in the investigation were "therapeutic ultrasound", " low-intensity pulsed ultrasound", and various words related to oral and dental disease (oral submucosal fibrosis, burning mouth syndrome, periodontitis, orthodontic tooth movement, and tooth trauma or caries). RESULTS: Therapeutic ultrasound, particularly low-intensity pulsed ultrasound (LIPUS), showed beneficial effects in interfering with pathological fibrosis, suppressing inflammatory responses, promoting periodontal tissue regeneration, and facilitating the repair of dentin-pulp complex injuries in oral and dental diseases. CLINICAL SIGNIFICANCE: Therapeutic ultrasound, particularly low-intensity pulsed ultrasound (LIPUS), showed beneficial effects in interfering with oral and dental diseases and may become an important adjunctive treatment modality in oral and dental medicine in the future.