Telerehabilitation in Pulmonary Arterial Hypertension

Study Design & Objectives: This is a multicenter, prospective, single‐arm interventionalstudy evaluating the safety, feasibility, and clinical effects of an 8‐week multimodaltelerehabilitation program in patients with stable Group 1 pulmonary arterialhypertension (PAH).Participant Population: The study will recruit adults with confirmed Group 1 PAH(idiopathic, heritable, connective tissue disease‐associated, or repaired congenitalheart disease‐associated) in World Health Organization (WHO) functional class II‐III whoare clinically stable on optimized medical therapy.Intervention Protocol: Participants will complete an 8‐week home‐based telerehabilitationprogram via a dedicated mobile application, consisting of three 60‐minute sessions perweek combining respiratory physiotherapy, inspiratory muscle training, strength andfunctional exercises, coordination, aerobic walking, and flexibility exercises. Oneweekly session will be supervised live via videoconference by an experiencedphysiotherapist, while the remaining two sessions will use pre‐recorded modules.Assessments & Outcomes: Evaluations occur at baseline, immediately post‐intervention, andat a 6‐month follow‐up. The primary endpoint is peak oxygen consumption ($VO_2peak$)measured via cardiopulmonary exercise testing (CPET), with secondary outcomes including6‐minute walk distance, ventilatory efficiency, health‐related quality of life (SF‐36 andCAMPHOR questionnaires), physical activity levels, inflammatory and myocardial stressbiomarkers, and safety/adverse events.